In this sermon, Pastor Dudley Rutherford emphasizes the importance of God’s will in maintaining sanctity and holiness, focusing on Thessalonica’s context of sexual immorality. He distinguishes between justification (righteousness through faith) and sanctification (the Holy Spirit’s ongoing work in transforming lives). Pastor Dudley warns against rejecting God’s instructions, urges nonbelievers to accept Jesus, and encourages believers to strive for purity.